Research Publications
My research investigates the cellular and circuit-level mechanisms underlying memory formation, synaptic plasticity, and cognitive flexibility, with a focus on dopamine signaling within the hippocampus and broader forebrain. I’m particularly interested in how neuromodulators shape context-dependent learning and how the disruption of these pathways may lead to memory generalization. By leveraging region-specific genetic knockouts, in vivo electrophysiology, and reinforcement learning, my work has helped parse the distinct roles of D1 and D5 dopamine receptors, offering mechanistic insight into the brain discriminates between what matters and what doesn’t.
Below are research articles that I have authored or I am an author on. Click on the title to directly access the PDF.
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Neural Synchrony of Minds and Machines: Hippocampal Mechanisms to Advance AI and Virtual Networks - Leonardo
Joshua Sariñana
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Differentiation of Forebrain and Hippocampal Dopamine 1-Class Receptors, D1R and D5R, in Spatial Learning and Memory - Hippocampus
Joshua Sariñana and Susumu Tonegawa
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Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory - PNAS
Joshua Sariñana, Takashi Kitamura, Patrik Künzler, Lisa Sultzman, and Susumu Tonegawa
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Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors - J. Neurophysiol.
Erin E. Gray, Ann E. Fink, Joshua Sariñana, Bryce Vissel, and Thomas J. O’Dell
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Activity-Dependent Depression of Local Excitatory Connections in the CA1 Region of Mouse Hippocampus - J. Neurophysiol.
Ann E. Fink, Joshua Sariñana, Erin E. Gray, and Thomas J. O’Dellscription goes here
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Carbonaceous meteorites as a source of sugar-related organic compounds for the early Earth - Nature
George Cooper, Novelle Kimmich, Warren Belisle, Josh Sariñana, Katrina Brabham & Laurence Garrel
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The Role of Dopamine in Hippocampus and Prefrontal Cortex Dependent Learning - NSF GRFP Proposal (Honorable Mention)
Joshua Sariñana